United States securities and exchange commission logo September 21, 2022 Terrence A. Duffy Chief Executive Officer CME Group Inc. 20 South Wacker Drive Chicago, Illinois 60606 Re: CME Group Inc. Definitive Proxy Statement on Schedule 14A Filed March 17, 2022 File No. 001-31553 Dear Mr. Duffy: We have limited our review of your most recent definitive proxy statement to those issues we have addressed in our comments. Please respond to these comments by confirming that you will enhance your future proxy disclosures in accordance with the topics discussed below as well as any material developments to your risk oversight structure. For guidance, refer to Item 407(h) of Regulation S-K. Definitive Proxy Statement on Schedule 14A filed March 17, 2022 General 1. Please expand your discussion of the reasons you believe that your leadership structure is appropriate, addressing your specific characteristics or circumstances. In your discussion, please also address how the experience of your Lead Director is brought to bear in connection with your board s role in risk oversight. 2. Please expand upon the role that your Lead Director plays in the leadership of the board. For example, please enhance your disclosure to address whether or not your Lead Director may: represent the board in communications with shareholders and other stakeholders; and require board consideration of, and/or override your CEO on, any risk matters. 3. Please expand upon how your board administers its risk oversight function. For example, please disclose: the specific risks over which the board elected to retain direct oversight responsibility and why oversight of those risks was not assigned to a board committee; the timeframe over which you evaluate risks (e.g., short-term, intermediate-term, or Terrence A. Duffy CME Group Inc. September 21, 2022 Page 2 long-term) and how you apply different oversight standards based upon the immediacy of the risk assessed; whether you consult with outside advisors and experts to anticipate future threats and trends, and how often you re-assess your risk environment; how the board interacts with management to address existing risks and identify significant emerging risks; whether you have a Chief Compliance Officer and to whom this position reports; and how your risk oversight process aligns with your disclosure controls and procedures. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Amanda Ravitz at 202-551-3412 or Barbara Jacobs at 202-551-3735 with any questions. FirstName LastNameTerrence A. Duffy Sincerely, Comapany NameCME Group Inc. Division of Corporation Finance September 21, 2022 Page 2 Disclosure Review Program FirstName LastName